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MIF demonstrates chemokine-like function and was discovered as being a ligand of the two CXCR2 and CXCR4. Binding of MIF to those receptors enhances monocyte recruitment and leukocyte chemotaxis (Figure one). In human chondrosarcoma cells, this recruitment is mediated by Gαi proteins and PI3K in T mobile adhesion by means of upregulation with the